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Methodology

From sample collection to scientific interpretation

A transparent, end-to-end account of how a swab or stool sample becomes sequencing-derived microbial context — with quality control, reference cohorts, and confidence indicators documented at each step.

We publish our methodology so that results can be judged on their process, not just their presentation. This page walks through collection, laboratory processing, extraction, sequencing, quality control, and the interpretation framework that turns validated data into readable context. Outputs describe associations, not causation, and are never intended to diagnose, treat, or cure.

Standardized collectionMolecular extractionSequencing preparationQuality controlATLAS interpretation

Scientific Principles

Restraint, traceability, and honest uncertainty guide every decision from bench to report.

Three principles hold the methodology together. First, traceability: each insight can be followed back to the sequencing signal and reference cohort it came from. Second, calibrated confidence: results carry indicators that show how strongly a pattern can be read, so nothing is overstated. Third, bounded scope: we report sequencing-derived microbial context and clearly mark where interpretation ends. These principles keep the science useful for curious readers and defensible for healthcare professionals reviewing the same data.

Sample Collection

Sample Collection explains the scientific role this topic plays within VAMS BIOME’s microbiome intelligence architecture.

Sample Collection presents the scientific workflow behind VAMS BIOME, from collection and laboratory processing through sequencing, quality control, computational analysis, and reporting.

Laboratory Processing

Laboratory Processing explains the scientific role this topic plays within VAMS BIOME’s microbiome intelligence architecture.

Laboratory Processing presents the scientific workflow behind VAMS BIOME, from collection and laboratory processing through sequencing, quality control, computational analysis, and reporting.

Derived from sequencing data. For educational and informational use only; not intended for diagnosis or treatment.

DNA & RNA Extraction

DNA & RNA Extraction explains the scientific role this topic plays within VAMS BIOME’s microbiome intelligence architecture.

DNA & RNA Extraction presents the scientific workflow behind VAMS BIOME, from collection and laboratory processing through sequencing, quality control, computational analysis, and reporting.

Sequencing Technologies

Sequencing Technologies explains the scientific role this topic plays within VAMS BIOME’s microbiome intelligence architecture.

Sequencing Technologies presents the scientific workflow behind VAMS BIOME, from collection and laboratory processing through sequencing, quality control, computational analysis, and reporting.

Derived from sequencing data. For educational and informational use only; not intended for diagnosis or treatment.

Quality Control

Quality Control explains the scientific role this topic plays within VAMS BIOME’s microbiome intelligence architecture.

Quality Control presents the scientific workflow behind VAMS BIOME, from collection and laboratory processing through sequencing, quality control, computational analysis, and reporting.

Interpretation Framework

Interpretation Framework explains the scientific role this topic plays within VAMS BIOME’s microbiome intelligence architecture.

Interpretation Framework presents the scientific workflow behind VAMS BIOME, from collection and laboratory processing through sequencing, quality control, computational analysis, and reporting.

See the methodology behind every ATLAS™ read

Trace any result back to the sample, the sequencing method, and the reference cohort that shaped it — with confidence indicators visible throughout.

  • Standardized collection
  • Molecular extraction
  • Sequencing preparation
  • Quality control
  • ATLAS interpretation

Derived from sequencing data. For educational and informational use only; not intended for diagnosis or treatment.